I'm left-handed. Which is not that optimal for general use of computers, since they are designed for right-handed people. You use the external mouse with your stronger right hand, which means your weaker left hand stays on the left side of the keyboard, where most of the function keys are. I managed to adopt that. But now a much greater challenge awaits: learning to do the same with the trackpad.
When I bought my first Mac, I also went for the Mighty mouse, which more or less sucked. After some time I abandoned it and started using the trackpad, which is really cool since it also supports multi-touch gestures. The new Macs and their trackpads are a lot bigger, and their multi-touch even more capable, so I'm not even thinking about getting an external mouse. Besides, I think having your hands near the keyboard by using a trackpad makes your inputting (navigating and typing) a bit faster and more optimal, since you don't have to move that much. And of course, it's better if you use the trackpad with your right hand because of the keybeard function keys.
When Apple introduced the first iPhone, people were laughing at its underperforming capabilities. But the iPhone had something significant that made it the success as it is today. The outstanding capacitative display and amazing user experience, which set new standards for mobile industry. I'm not sure if the same capacitative technology is used in Mac trackpads, but the fact is they simply work.
Looking at modern tablets and smartphones, it's pretty obvious that the future lies in devices with touch capabilities. Why should computers be any different? Besides, we will probably be using both hands sometime soon. So this mission of mine may have multiple benefits. Be better today (ok, tomorrow, since adoption will take some time), and be prepared for the super high-tech virtual touch future by having two touch-adopted hands. And when I actually manage to make it work, I already have an idea for the next, even more optimal inputting method: Using the trackpad with my right thumb, so both my hands can stay on the keyboard. Wish me luck.